Esta es la lista completa de Autos y Pilotos para la Drydene 400 en el Dover International Speedway, sede de la 1ra. fecha de la Ronda de los 12 en los Playoffs Monster Energy NASCAR Cup Series 2019.
| No. | Piloto | Patrocinador | Fabricante | Organización |
| 00 | Landon Cassill | Clean Origin | Chevrolet | StarCom Racing |
| 1 | Kurt Busch | GearWrench | Chevrolet | Chip Ganassi Racing |
| 2 | Brad Keselowski | Wurth | Ford | Team Penske |
| 3 | Austin Dillon | AAA | Chevrolet | Richard Childress Racing |
| 4 | Kevin Harvick | Busch Beer All Harvick | Ford | Stewart-Haas Racing |
| 6 | Ryan Newman | Acronis | Ford | Roush Fenway Racing |
| 8 | Daniel Hemric | Lucas Oil | Chevrolet | Richard Childress Racing |
| 9 | Chase Elliott | Hooters Give a Hoot | Chevrolet | Hendrick Motorsports |
| 10 | Aric Almirola | Smithfield | Ford | Stewart-Haas Racing |
| 11 | Denny Hamlin | FedEx Express | Toyota | Joe Gibbs Racing |
| 12 | Ryan Blaney | PPG | Ford | Team Penske |
| 13 | Ty Dillon | GEICO | Chevrolet | Germain Racing |
| 14 | Clint Bowyer | ITsavvy / Haas | Ford | Stewart-Haas Racing |
| 15 | Ross Chastain | Low-T Center | Chevrolet | Premium Motorsports |
| 17 | Ricky Stenhouse Jr. | Fastenal | Ford | Roush Fenway Racing |
| 18 | Kyle Busch | Interstate Batteries | Toyota | Joe Gibbs Racing |
| 19 | Martin Truex Jr. | Bass Pro Shops | Toyota | Joe Gibbs Racing |
| 20 | Erik Jones | DeWalt | Toyota | Joe Gibbs Racing |
| 21 | Paul Menard | Menards / Cardell Cabinets | Ford | Wood Brothers Racing |
| 22 | Joey Logano | Shell Pennzoil | Ford | Team Penske |
| 24 | William Byron | Axalta | Chevrolet | Hendrick Motorsports |
| 27 | Joe Nemechek | TBA | Chevrolet | Premium Motorsports |
| 32 | Corey LaJoie | Drydene | Ford | Go Fas Racing |
| 34 | Michael McDowell | The Pete Store | Ford | Front Row Motorsports |
| 36 | Matt Tifft | Delaware Lottery / Surface | Ford | Front Row Motorsports |
| 37 | Chris Buescher | Kroger Simmer Like A Winner | Chevrolet | JTG Daugherty Racing |
| 38 | David Ragan | MDS Transport | Ford | Front Row Motorsports |
| 41 | Daniel Suarez | ARRIS | Ford | Stewart-Haas Racing |
| 42 | Kyle Larson | Clover | Chevrolet | Chip Ganassi Racing |
| 43 | Bubba Wallace | Victory Junction | Chevrolet | Richard Petty Motorsports |
| 47 | Ryan Preece | Kroger | Chevrolet | JTG Daugherty Racing |
| 48 | Jimmie Johnson | Ally | Chevrolet | Hendrick Motorsports |
| 51 | BJ McLeod | TBA | Ford | Petty Ware Racing |
| 52 | JJ Yeley | TBA | Ford | Rick Ware Racing |
| 54 | TBA | TBA | Chevrolet | Rick Ware Racing |
| 77 | Reed Sorenson | TBA | Chevrolet | Spire Motorsports |
| 88 | Alex Bowman | Cincinnati | Chevrolet | Hendrick Motorsports |
| 95 | Matt DiBenedetto | Dumont Jets | Toyota | Leavine Family Racing |