La siguiente es la lista de autos y pilotos para la Autos y pilotos para la 1000Bulbs.com 500 en el Talladega Superspeedway, sede de la 2da. fecha de la Ronda de los 12 de la Monster Energy NASCAR Cup Series 2019.
| No. | Piloto | Patrocinador | Fabricante | Organización |
| 00 | Landon Cassill | Graybar / Superior Essex | Chevrolet | StarCom Racing |
| 1 | Kurt Busch | Monster Energy | Chevrolet | Chip Ganassi Racing |
| 2 | Brad Keselowski | Miller Lite | Ford | Team Penske |
| 3 | Austin Dillon | American Ethanol / RCR 50th | Chevrolet | Richard Childress Racing |
| 4 | Kevin Harvick | Busch Light | Ford | Stewart-Haas Racing |
| 6 | Ryan Newman | Wyndham Rewards | Ford | Roush Fenway Racing |
| 8 | Daniel Hemric | Liberty National / RCR 50th | Chevrolet | Richard Childress Racing |
| 9 | Chase Elliott | NAPA Night Vision | Chevrolet | Hendrick Motorsports |
| 10 | Aric Almirola | Smithfield Racin’ for Bacon | Ford | Stewart-Haas Racing |
| 11 | Denny Hamlin | FedEx Ground | Toyota | Joe Gibbs Racing |
| 12 | Ryan Blaney | Dent Wizard | Ford | Team Penske |
| 13 | Ty Dillon | GEICO | Chevrolet | Germain Racing |
| 14 | Clint Bowyer | Rush / Mobil Delvac 1 | Ford | Stewart-Haas Racing |
| 15 | Ross Chastain | Low-T Center | Chevrolet | Premium Motorsports |
| 17 | Ricky Stenhouse Jr. | SunnyD | Ford | Roush Fenway Racing |
| 18 | Kyle Busch | M&M’s Hazelnut | Toyota | Joe Gibbs Racing |
| 19 | Martin Truex Jr. | Bass Pro Shops | Toyota | Joe Gibbs Racing |
| 20 | Erik Jones | Craftsman | Toyota | Joe Gibbs Racing |
| 21 | Paul Menard | Menards / Tarkett | Ford | Wood Brothers Racing |
| 22 | Joey Logano | Shell Pennzoil | Ford | Team Penske |
| 24 | William Byron | Axalta | Chevrolet | Hendrick Motorsports |
| 27 | Reed Sorenson | TBD | Chevrolet | Premium Motorsports |
| 32 | Corey LaJoie | TBD | Ford | Go Fas Racing |
| 34 | Michael McDowell | Love’s Travel Stops | Ford | Front Row Motorsports |
| 36 | Matt Tifft | Surface Sunscreen / Tunity | Ford | Front Row Motorsports |
| 37 | Chris Buescher | Louisiana Hot Sauce | Chevrolet | JTG Daugherty Racing |
| 38 | David Ragan | Envision | Ford | Front Row Motorsports |
| 41 | Daniel Suarez | Haas Automation | Ford | Stewart-Haas Racing |
| 42 | Kyle Larson | McDonald’s | Chevrolet | Chip Ganassi Racing |
| 43 | Bubba Wallace | Victory Junction | Chevrolet | Richard Petty Motorsports |
| 47 | Ryan Preece | Kroger | Chevrolet | JTG Daugherty Racing |
| 48 | Jimmie Johnson | Ally | Chevrolet | Hendrick Motorsports |
| 51 | Austin Theriault | Jacob Companies | Ford | Petty Ware Racing |
| 52 | Spencer Boyd | Medicine Shoppe | Chevrolet | Rick Ware Racing |
| 62 | Brendan Gaughan | Beard Oil / South Point Hotel | Chevrolet | Beard Motorsports |
| 66 | Joey Gase | Fan Memories at Richmond | Toyota | MBM Motorsports |
| 77 | Blake Jones | TBD | Chevrolet | Spire Motorsports |
| 88 | Alex Bowman | Nationwide / Amazon Echo | Chevrolet | Hendrick Motorsports |
| 95 | Matt DiBenedetto | One Bite | Toyota | Leavine Family Racing |
| 96 | Parker Kligerman | TRD 40th Anniversary | Toyota | Gaunt Brothers Racing |