Autos y pilotos para la Bojangles’ Southern 500 en el Darlington Raceway
| No. | Piloto | Patrocinador | Fabricante | Equipo |
| 00 | Landon Cassill | StarCom Fiber | Chevrolet | StarCom Racing |
| 1 | Kurt Busch | Chevrolet Accessories | Chevrolet | Chip Ganassi Racing |
| 2 | Brad Keselowski | Miller Lite | Ford | Team Penske |
| 3 | Austin Dillon | American Ethanol | Chevrolet | Richard Childress Racing |
| 4 | Kevin Harvick | Busch Beer / Big Buck Hunter | Ford | Stewart-Haas Racing |
| 6 | Ryan Newman | Oscar Mayer / Velveeta | Ford | Roush Fenway Racing |
| 8 | Daniel Hemric | Caterpillar | Chevrolet | Richard Childress Racing |
| 9 | Chase Elliott | NAPA Throwback | Chevrolet | Hendrick Motorsports |
| 10 | Aric Almirola | Smithfield | Ford | Stewart-Haas Racing |
| 11 | Denny Hamlin | FedEx Darlington Throwback | Toyota | Joe Gibbs Racing |
| 12 | Ryan Blaney | Menards/Pennzoil | Ford | Team Penske |
| 13 | Ty Dillon | GEICO | Chevrolet | Germain Racing |
| 14 | Clint Bowyer | Rush Truck Centers / Mobil 1 | Ford | Stewart-Haas Racing |
| 15 | Ross Chastain | TBA | Chevrolet | Premium Motorsports |
| 17 | Ricky Stenhouse Jr. | Dog’s Most Wanted | Ford | Roush Fenway Racing |
| 18 | Kyle Busch | Snickers Throwback | Toyota | Joe Gibbs Racing |
| 19 | Martin Truex Jr. | Bass Pro Shops | Toyota | Joe Gibbs Racing |
| 20 | Erik Jones | Sports Clips Throwback | Toyota | Joe Gibbs Racing |
| 21 | Paul Menard | Motorcraft / Quick Lane | Ford | Wood Brothers Racing |
| 22 | Joey Logano | Shell Pennzoil | Ford | Team Penske |
| 24 | William Byron | City Chevrolet Throwback | Chevrolet | Hendrick Motorsports |
| 27 | Joe Nemechek | TBA | Chevrolet | Premium Motorsports |
| 32 | Corey LaJoie | CorvetteParts.net | Ford | Go Fas Racing |
| 34 | Michael McDowell | Dockside Logistics | Ford | Front Row Motorsports |
| 36 | Matt Tifft | Hilliker Glass / Surface | Ford | Front Row Motorsports |
| 37 | Chris Buescher | Kroger Fast Lane to Flavor | Chevrolet | JTG Daugherty Racing |
| 38 | David Ragan | Shriners Hospital for Children | Ford | Front Row Motorsports |
| 41 | Daniel Suarez | Haas Automation | Ford | Stewart-Haas Racing |
| 42 | Kyle Larson | Clover | Chevrolet | Chip Ganassi Racing |
| 43 | Bubba Wallace | Victory Junction 15th Anniversary | Chevrolet | Richard Petty Motorsports |
| 47 | Ryan Preece | Kroger | Chevrolet | JTG Daugherty Racing |
| 48 | Jimmie Johnson | Ally Throwback | Chevrolet | Hendrick Motorsports |
| 51 | BJ McLeod | Jacob Companies | Ford | Petty Ware Racing |
| 52 | JJ Yeley | Jacob companies | Ford | Rick Ware Racing |
| 54 | Garrett Smithley | AQRE | Chevrolet | Rick Ware Racing |
| 66 | Joey Gase | MBM Motorsports | Toyota | MBM |
| 77 | Reed Sorenson | Motor Racing Network | Chevrolet | Spire Motorsports |
| 88 | Alex Bowman | Axalta Throwback | Chevrolet | Hendrick Motorsports |
| 95 | Matt DiBenedetto | No. 95 IMSA GTO Throwback | Toyota | Leavine Family Racing |